Creatine Activity as a Neuromodulator in the Central Nervous System

Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated similar to neurotransmitters, creatine released in an excitotoxic action potential-dependent manner acts as neuromodulator. deficiency syndromes are characterized by severe mental developmental disorders. Studies have reported brain content could be enhanced with supplementation. Nevertheless, there still limited knowledge about the effects of on central nervous system. However, ample proved neuroprotective various aspects, such cognition, memory skills, spatial memory. The present review aimed available experimental data clinical observations confirming roles transmission process. A systematic search literature was performed PubMed, Scopus, Embase, Cochrane Library, Web Science, Google Scholar database using all MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, Neuroprotection. Electronic searches were combined duplicates removed. Here, first, its potential influence health performance briefly reviewed. Next, existing specifically explored understand how interact neurotransmitter revealed exogenous supplementation decreases neuronal cell loss paradigms neurological diseases. It observed N-methyl-D-aspartate receptor, Na+-K+-ATPase enzyme, GABAA serotonin 1A receptors, presumably α1-adrenoceptor play critical process which implies can considered